http://www.stemcells.com Stem Cells current issue RSS Feed http://www.stemcells.com/details/journalArticle/739473/Induced_Pluripotent_Stem_Cells__It_Looks_Simple_but_Can_Looks_Deceive.html 2010-03-16T00:00:00Z http://www.stemcells.com/details/journalArticle/685913/Launch_of_the_New_Stem_Cells_Portal.html 2010-03-16T00:00:00Z http://www.stemcells.com/details/journalArticle/678431/Law_Ethics_Religion_and_Clinical_Translation_in_the_21st_CenturyA_Discussion_wit.html 2010-02-17T00:00:00Z http://www.stemcells.com/details/journalArticle/571491/Law_Ethics_Religion_and_Clinical_Translation_in_the_21st_CenturyA_Discussion_wit.html 2010-01-13T00:00:00Z http://www.stemcells.com/details/journalArticle/113256/S_ells_Appoints_Four_Associate_Editors.html 2008-04-18T00:00:00Z http://www.stemcells.com/details/journalArticle/113286/Concise_Review_Adult_Multipotent_Stromal_Cells_and_Cancer_Risk_or_Benefit.html Abstract This review focuses on the interaction between multipotent stromal cells (MSCs) and carcinoma and the possible use of MSCs in cell‐based anticancer therapies. MSCs are present in multiple tissues and are defined as cells displaying the ability to differentiate in multiple lineages, including chondrocytes, osteoblasts, and adipocytes. Recent evidence also suggests that they could play a role in the progression of... 2008-04-03T00:00:00Z http://www.stemcells.com/details/journalArticle/113678/Runx1_Protects_Hematopoietic_StemProgenitor_Cells_from_Oncogenic_Insult.html Abstract The RUNX1/AML1 gene encodes a transcription factor essential for the generation of hematopoietic stem cells and is frequently targeted in human leukemia. In human RUNX1‐related leukemias, the RAS pathway is often concurrently mutated, but the mechanism of the synergism remains elusive. Here, we found that inactivation of Runx1 in mouse bone marrow cells results in an increase in the stem/progenitor cell fraction due to suppression of... 2007-09-06T00:00:00Z http://www.stemcells.com/details/journalArticle/113413/Stem_Cell_Science_and_the_Lasker_AwardLet_the_Science_Not_Be_Lost_in_Translation.html 2007-04-01T00:00:00Z http://www.stemcells.com/details/journalArticle/113349/2006_Just_the_Facts.html 2007-01-11T00:00:00Z http://www.stemcells.com/details/journalArticle/113445/Concise_Review_Regulation_of_Embryonic_Stem_Cell_Lineage_Commitment_by_MitogenAc.html Abstract Embryonic stem (ES) cells can give rise, in vivo, to the ectodermal, endodermal, and mesodermal germ layers and, in vitro, can differentiate into multiple cell lineages, offering broad perspectives in regenerative medicine. Understanding the molecular mechanisms governing ES cell commitment is an essential challenge in this field. The mitogen‐activated protein kinase (MAPK) pathways extracellular signal‐regulated kinase... 2007-01-11T00:00:00Z http://www.stemcells.com/details/journalArticle/113316/S_ells__A_Quarter_Century_of_Progress.html 2007-01-01T00:00:00Z http://www.stemcells.com/details/journalArticle/113383/Concise_Review_Embryonic_Stem_Cells_A_New_Tool_to_Study_Osteoblast_and_Osteoclas.html Abstract Bone remodeling involves synthesis of organic matrix by osteoblasts and bone resorption by osteoclasts. A tight collaboration between these two cell types is essential to maintain a physiological bone homeostasis. Thus, osteoblasts control bone‐resorbing activities and are also involved in osteoclast differentiation. Any disturbance between these effectors leads to the development of skeletal abnormalities and/or bone... 2006-11-09T00:00:00Z http://www.stemcells.com/details/journalArticle/113869/Troublesome_Questions.html 2006-06-01T00:00:00Z http://www.stemcells.com/details/journalArticle/113838/Cellular_Memory_and_Hematopoietic_Stem_Cell_Aging.html Abstract Hematopoietic stem cells (HSCs) balance self‐renewal and differentiation in order to sustain lifelong blood production and simultaneously maintain the HSC pool. However, there is clear evidence that HSCs are subject to quantitative and qualitative exhaustion. In this review, we briefly discuss several known aspects of the stem cell aging process, including DNA damage, telomere shortening, and oxidative stress. Besides these... 2006-02-02T00:00:00Z http://www.stemcells.com/details/journalArticle/113762/Role_and_Function_of_Matrix_Metalloproteinases_in_the_Differentiation_and_Biolog.html Abstract Matrix metalloproteinases (MMPs), known as matrixins, are Ca‐ and Zn‐dependent endoproteinases involved in a wide variety of developmental and disease‐associated processes, proving to be crucial protagonists in many physiological and pathological mechanisms. The ability of MMPs to alter, by limited proteolysis and through the fine control of tissue inhibitors of metalloproteinases, the activity or function of numerous... 2005-09-08T00:00:00Z