Virtual Issues

To read an issue, click on the link above or choose it from the menu below.

 

Translational and Clinical Research

 

Concise Review: Adipose Tissue-Derived Stromal Cells - Basic and Clinical Implications for Novel Cell-Based Therapies
Andreas Schäffler, Christa Büchler

Concise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair - Current Views
Donald G. Phinney, Darwin J. Prockop

Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+ Regulatory T Cells
Zohair Selmani, Abderrahim Naji, Ines Zidi, Benoit Favier, Emilie Gaiffe, Laurent Obert, Christophe Borg, Philippe Saas, Pierre Tiberghien, Nathalie Rouas-Freiss, Edgardo D. Carosella, Frederic Deschaseaux

Persistent Dopamine Functions of Neurons Derived from Embryonic Stem Cells in a Rodent Model of Parkinson Disease
Jose A. Rodríguez-Gómez, Jian-Qiang Lu, Iván Velasco, Seth Rivera, Sami S. Zoghbi, Jeih-San Liow, John L. Musachio, Frederick T. Chin, Hiroshi Toyama, Jurgen Seidel, Michael V. Green, Panayotis K. Thanos, Masanori Ichise, Victor W. Pike, Robert B. Innis, Ron D. G. McKay

Mesenchymal Stem Cells Inhibit the Differentiation of Dendritic Cells Through an Interleukin-6-Dependent Mechanism
Farida Djouad, Louis-Marie Charbonnier, Carine Bouffi, Pascale Louis-Plence, Claire Bony, Florence Apparailly, Céline Cantos, Christian Jorgensen, Danièle Noël

Human AB Serum and Thrombin-Activated Platelet-Rich Plasma Are Suitable Alternatives to Fetal Calf Serum for the Expansion of Mesenchymal Stem Cells from Adipose Tissue
Asli Kocaoemer, Susanne Kern, Harald Klüter, Karen Bieback

Cells Isolated from Umbilical Cord Tissue Rescue Photoreceptors and Visual Functions in a Rodent Model of Retinal Disease
Raymond D. Lund, Shaomei Wang, Bin Lu, Sergej Girman, Toby Holmes, Yves Sauvé, Darin J. Messina, Ian R. Harris, Anthony J. Kihm, Alexander M. Harmon, Feng-Yi Chin, Anna Gosiewska, Sanjay K. Mistry

Concise Review: No Breakthroughs for Human Mesenchymal and Embryonic Stem Cell Culture: Conditioned Medium, Feeder Layer, or Feeder-Free; Medium with Fetal Calf Serum, Human Serum, or Enriched Plasma; Serum-Free, Serum Replacement Nonconditioned Medium, or Ad Hoc Formula? All That Glitters Is Not Gold!
Ferdinando Mannello, Gaetana A. Tonti

MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1
Yvonne M.-S. Tay, Wai-Leong Tam, Yen-Sin Ang, Philip M. Gaughwin, Henry Yang, Weijia Wang, Rubing Liu, Joshy George, Huck-Hui Ng, Ranjan J. Perera, Thomas Lufkin, Isidore Rigoutsos, Andrew M. Thomson, Bing Lim

Concise Review: Therapeutic Strategies for Parkinson Disease Based on the Modulation of Adult Neurogenesis
Martine Geraerts, Olga Krylyshkina, Zeger Debyser, Veerle Baekelandt

Concise Review: Isolation and Characterization of Cells from Human Term Placenta: Outcome of the First International Workshop on Placenta Derived Stem Cells
Ornella Parolini, Francesco Alviano, Gian Paolo Bagnara, Grozdana Bilic, Hans-Jörg Bühring, Marco Evangelista, Simone Hennerbichler, Bing Liu, Marta Magatti, Ning Mao, Toshio Miki, Fabio Marongiu, Hideaki Nakajima, Toshio Nikaido, C. Bettina Portmann-Lanz, Venkatachalam Sankar, Maddalena Soncini, Guido Stadler, Daniel Surbek, Tsuneo A. Takahashi, Heinz Redl, Norio Sakuragawa, Susanne Wolbank, Steffen Zeisberger, Andreas Zisch, Stephen C. Strom

Isolation and Molecular Characterization of Cancer Stem Cells in MMTV-Wnt-1 Murine Breast Tumors
Robert W. Cho, Xinhao Wang, Maximilian Diehn, Kerby Shedden, Grace Y. Chen, Gavin Sherlock, Austin Gurney, John Lewicki, Michael F. Clarke

Spheres Isolated from 9L Gliosarcoma Rat Cell Line Possess Chemoresistant and Aggressive Cancer Stem-Like Cells
Ali Jourabchi Ghods, Dwain Irvin, Gentao Liu, Xiangpeng Yuan, Iman R. Abdulkadir, Patrizia Tunici, Bindu Konda, Sebastian Wachsmann-Hogiu, Keith L. Black, John S. Yu

N-Glycolylneuraminic Acid Xenoantigen Contamination of Human Embryonic and Mesenchymal Stem Cells Is Substantially Reversible
Annamari Heiskanen, Tero Satomaa, Sari Tiitinen, Anita Laitinen, Sirkka Mannelin, Ulla Impola, Milla Mikkola, Cia Olsson, Halina Miller-Podraza, Maria Blomqvist, Anne Olonen, Hanna Salo, Petri Lehenkari, Timo Tuuri, Timo Otonkoski, Jari Natunen, Juhani Saarinen, Jarmo Laine

Multipotent Stem Cells from Umbilical Cord: Cord Is Richer than Blood!
Mariane Secco, Eder Zucconi, Natassia M. Vieira, Luciana L.Q. Fogaça, Antonia Cerqueira, Maria Denise F. Carvalho, Tatiana Jazedje, Oswaldo K. Okamoto, Alysson R. Muotri, Mayana Zatz

Concise Review: Prospects of Stem Cell Therapy for Temporal Lobe Epilepsy
shok K. Shetty, Bharathi Hattiangady

Complete Spinal Cord Injury Treatment Using Autologous Bone Marrow Cell Transplantation and Bone Marrow Stimulation with Granulocyte Macrophage-Colony Stimulating Factor: Phase I/II Clinical Trial
Seung Hwan Yoon, Yu Shik Shim, Yong Hoon Park, Jong Kwon Chung, Jung Hyun Nam, Myung Ok Kim, Hyung Chun Park, So Ra Park, Byoung-Hyun Min, Eun Young Kim, Byung Hyune Choi, Hyeonseon Park, Yoon Ha

Xenotransplantation of Long-Term-Cultured Swine Bone Marrow-Derived Mesenchymal Stem Cells
Yasuhiro Nakamura, Xiaohong Wang, Chengsu Xu, Atsushi Asakura, Minoru Yoshiyama, Arthur H.L. From, Jianyi Zhang

Molecular Profiling of CD34+ Cells in Idiopathic Myelofibrosis Identifies a Set of Disease-Associated Genes and Reveals the Clinical Significance of Wilms' Tumor Gene 1 (WT1)
Paola Guglielmelli, Roberta Zini, Costanza Bogani, Simona Salati, Alessandro Pancrazzi, Elisa Bianchi, Francesco Mannelli, Sergio Ferrari, Marie-Caroline Le Bousse-Kerdilès, Alberto Bosi, Giovanni Barosi, Anna Rita Migliaccio, Rossella Manfredini, Alessandro M. Vannucchi

Toll-Like Receptors on Human Mesenchymal Stem Cells Drive Their Migration and Immunomodulating Responses
Suzanne L. Tomchuck, Kevin J. Zwezdaryk, Seth B. Coffelt, Ruth S. Waterman, Elizabeth S. Danka, Aline B. Scandurro

 

Cancer Stem Cells

 

Sarcoma Derived from Cultured Mesenchymal Stem Cells
Jakub Tolar, Alma J. Nauta, Mark J. Osborn, Angela Panoskaltsis Mortari, Ron T. McElmurry, Scott Bell, Lily Xia, Ning Zhou, Megan Riddle, Tania M. Schroeder, Jennifer J. Westendorf, R. Scott McIvor, Pancras C.W. Hogendoorn, Karoly Szuhai, LeAnn Oseth, Betsy Hirsch, Stephen R. Yant, Mark A. Kay, Alexandra Peister, Darwin J. Prockop, Willem E. Fibbe, Bruce R. Blazar

Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma
Eli E. Bar, Aneeka Chaudhry, Alex Lin, Xing Fan, Karisa Schreck, William Matsui, Sara Piccirillo, Angelo L. Vescovi, Francesco DiMeco, Alessandro Olivi, Charles G. Eberhart

Concise Review: Multipotent Mesenchymal Stromal Cells in Blood
Qiling He, Chao Wan, Gang Li

Differential Gene Expression Associated with Migration of Mesenchymal Stem Cells to Conditioned Medium from Tumor Cells or Bone Marrow Cells
Lata G. Menon, Sonia Picinich, Rajeth Koneru, Hui Gao, Siang Yo Lin, Mythili Koneru, Philipp Mayer-Kuckuk, John Glod, Debabrata Banerjee

Spontaneous Transformation of Human Adult Nontumorigenic Stem Cells to Cancer Stem Cells Is Driven by Genomic Instability in a Human Model of Glioblastoma
Anjali Shiras, Sivarajan T Chettiar, Varsha Shepal, Ganeshkumar Rajendran, G. Rajendra Prasad, Padma Shastry

Isolation and Molecular Characterization of Cancer Stem Cells in MMTV-Wnt-1 Murine Breast Tumors
obert W. Cho, Xinhao Wang, Maximilian Diehn, Kerby Shedden, Grace Y. Chen, Gavin Sherlock, Austin Gurney, John Lewicki, Michael F. Clarke

Spheres Isolated from 9L Gliosarcoma Rat Cell Line Possess Chemoresistant and Aggressive Cancer Stem-Like Cells
AAli Jourabchi Ghods, Dwain Irvin, Gentao Liu, Xiangpeng Yuan, Iman R. Abdulkadir, Patrizia Tunici, Bindu Konda, Sebastian Wachsmann-Hogiu, Keith L. Black, John S. Yu

Concise Review: Stem Cell Antigen-1: Expression, Function, and Enigma
Christina Holmes, William L. Stanford

Identification of a Novel Putative Gastrointestinal Stem Cell and Adenoma Stem Cell Marker, Doublecortin and CaM Kinase-Like-1, Following Radiation Injury and in Adenomatous Polyposis Coli/Multiple Intestinal Neoplasia Mice
Randal May, Terrence E. Riehl, Clayton Hunt, Sripathi M. Sureban, Shrikant Anant, Courtney W. Houchen

Concise Review: Roles of Polycomb Group Proteins in Development and Disease: A Stem Cell Perspective
Vinagolu K. Rajasekhar, Martin Begemann

p66Shc/Notch-3 Interplay Controls Self-Renewal and Hypoxia Survival in Human Stem/Progenitor Cells of the Mammary Gland Expanded In Vitro as Mammospheres
Pasquale Sansone, Gianluca Storci, Catia Giovannini, Silvia Pandolfi, Simona Pianetti, Mario Taffurelli, Donatella Santini, Claudio Ceccarelli, Pasquale Chieco, Massimiliano Bonafé

Bmi-1-Green Fluorescent Protein-Knock-In Mice Reveal the Dynamic Regulation of Bmi-1 Expression in Normal and Leukemic Hematopoietic Cells
Naoki Hosen, Toshiyuki Yamane, Manja Muijtjens, Kara Pham, Michael F. Clarke, Irving L. Weissman

Bone Marrow Contributes to Epithelial Cancers in Mice and Humans as Developmental Mimicry
Christopher R. Cogle, Neil D. Theise, DongTao Fu, Deniz Ucar, Sean Lee, Steven M. Guthrie, Jean Lonergan, Witold Rybka, Diane S. Krause, Edward W. Scott

Donor-Derived Human Bone Marrow Cells Contribute to Solid Organ Cancers Developing After Bone Marrow Transplantation
Itzhak Avital, Andre L. Moreira, David S. Klimstra, Margaret Leversha, Esperanza B. Papadopoulos, Murray Brennan, Robert J. Downey

Concise Review: Wharton's Jelly-Derived Cells Are a Primitive Stromal Cell Population
Deryl L. Troyer, Mark L. Weiss

Absence of OCT4 Expression in Somatic Tumor Cell Lines
Tobias Cantz, Göran Key, Martina Bleidibetael, Luca Gentile, Dong Wook Han, Alexandra Brenne, Hans R. Schöler

Sonic Hedgehog Stimulates Mouse Embryonic Stem Cell Proliferation by Cooperation of Ca2+/Protein Kinase C and Epidermal Growth Factor Receptor As Well as Gli1 Activation
Jung Sun Heo, Min Young Lee, Ho Jae Han

Enhanced Unique Pattern of Hematopoietic Cell Mobilization Induced by the CXCR4 Antagonist 4F-Benzoyl-TN14003
Michal Abraham, Katia Biyder, Michal Begin, Hanna Wald, Ido D. Weiss, Eithan Galun, Arnon Nagler, Amnon Peled

Concise Review: Cancer/Testis Antigens, Stem Cells, and Cancer
Fabrício F. Costa, Katarina Le Blanc, Bertha Brodin

Concise Review: Adult Multipotent Stromal Cells and Cancer: Risk or Benefit?
Gwendal Lazennec, Christian Jorgensen

 

Key Papers From Asia in Stem Cells and Regenerative Medicine

 

Editors' Note:

The Editors are pleased to produce this Virtual Issue that reprints key peer-accepted publications devoted to stem cells and regenerative medicine. The issue covers many fields, including:

♦ Neural Induction with Neurogenin1 Increases the Therapeutic Effects of Mesenchymal Stem Cells in the Ischemic Brain

♦ Mesenchymal stem cells alter migratory property of T and dendritic cells to delay the development of murine lethal acute graft-versus-host disease

♦ Robo4 is expressed on hematopoietic stem cells and potentially involved in the niche-mediated regulation of the side population phenotype

♦ CD105 positive cells in pulmonary arterial blood of adult human lung cancer patients include mesenchymal progenitors

♦ Human Embryonic Stem Cell-Derived Mesenchymal Progenitors (EMPs) Possess Strong Immunosuppressive Effects Towards Natural Killer Cells as well as T Lymphocytes

IFATS Collection: Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells in an Allergic Rhinitis Mouse Model
Kyu-Sup Cho, Hye-Kyung Park, Hee-Young Park, Jin Sup Jung, Seong-Gyu Jeon, Yoon-Keun Kim, Hwan Jung Roh

Thromboxane A2 Induces Differentiation of Human Mesenchymal Stem Cells to Smooth Muscle-Like Cells
Mi Ra Kim, Eun Su Jeon, Young Mi Kim, Jung Sub Lee, Jae Ho Kim

Notch Inhibition Promotes Human Embryonic Stem Cell-Derived Cardiac Mesoderm Differentiation
Jiho Jang, Seung Yup Ku, Jung Eun Kim, Kyunghee Choi, Yoon Young Kim, Hee Sun Kim, Sun Kyung Oh, Eun Ju Lee, Hyun-Jai Cho, Young Hwan Song, Sang Hun Lee, Suk Ho Lee, Chang Suk Suh, Seok Hyun Kim, Shin Yong Moon, Young Min Choi

Neural Induction with Neurogenin1 Increases the Therapeutic Effects of Mesenchymal Stem Cells in the Ischemic Brain
Sung-Soo Kim, Seung-Wan Yoo, Tae-Seok Park, Seung-Cheol Ahn, Han-Seong Jeong, Ji-Won Kim, Da-Young Chang, Kyung-Gi Cho, Seung U. Kim, Youngbuhm Huh, Jong-Eun Lee, Soo-Yeol Lee, Young-Don Lee, Haeyoung Suh-Kim

IFATS Collection: Selenium Induces Improvement of Stem Cell Behaviors in Human Adipose-Tissue Stromal Cells via SAPK/JNK and Stemness Acting Signals
Jeong Hwan Kim, Mi Ran Lee, Jee Hun Kim, Min Ki Jee, Soo Kyung Kang

TIS21/BTG2 Negatively Regulates Estradiol-Stimulated Expansion of Hematopoietic Stem Cells by Derepressing Akt Phosphorylation and Inhibiting mTOR Signal Transduction
Bong Cho Kim, Min Sook Ryu, S. Paul Oh, In Kyoung Lim

Osteopontin Promotes the Development of Natural Killer Cells from Hematopoietic Stem Cells
Jin Woong Chung, Mi Sun Kim, Zheng-Hao Piao, Mira Jeong, Suk Ran Yoon, Nara Shin, Sang Yong Kim, Eun Sook Hwang, Young Yang, Young Ho Lee, Young Sang Kim, Inpyo Choi

Pluripotin Combined with Leukemia Inhibitory Factor Greatly Promotes the Derivation of Embryonic Stem Cell Lines from Refractory Strains
Weifeng Yang, Wei Wei, Cheng Shi, Jinliang Zhu, Wenqin Ying, Yan Shen, Xin Ye, Lingling Fang, Shuguang Duo, Jie Che, Huan Shen, Sheng Ding, Hongkui Deng

Mesenchymal Stem Cells Alter Migratory Property of T and Dendritic Cells to Delay the Development of Murine Lethal Acute Graft-Versus-Host Disease
Hong Li, ZiKuan Guo, XiaoXia Jiang, Heng Zhu, XiuSen Li, Ning Mao

A Feeder-Free and Efficient Production of Functional Neutrophils from Human Embryonic Stem Cells
Koichi Saeki, Kumiko Saeki, Masako Nakahara, Satoko Matsuyama, Naoko Nakamura, Yoshiko Yogiashi, Asako Yoneda, Makoto Koyanagi, Yasushi Kondo, Akira Yuo

Roundabout 4 Is Expressed on Hematopoietic Stem Cells and Potentially Involved in the Niche-Mediated Regulation of the Side Population Phenotype
Fumi Shibata, Yuko Goto-Koshino, Yoshihiro Morikawa, Tadasuke Komori, Miyuki Ito, Yumi Fukuchi, Jeffrey P. Houchins, Monica Tsang, Dean Y. Li, Toshio Kitamura, Hideaki Nakajima

Quiescent Human Hematopoietic Stem Cells in the Bone Marrow Niches Organize the Hierarchical Structure of Hematopoiesis
Takashi Yahata, Yukari Muguruma, Shizu Yumino, Yin Sheng, Tomoko Uno, Hideyuki Matsuzawa, Mamoru Ito, Shunichi Kato, Tomomitsu Hotta, Kiyoshi Ando

IFATS Collection: Fibroblast Growth Factor-2-Induced Hepatocyte Growth Factor Secretion by Adipose-Derived Stromal Cells Inhibits Postinjury Fibrogenesis Through a c-Jun N-Terminal Kinase-Dependent Mechanism Stem Cells
Hirotaka Suga, Hitomi Eto, Tomokuni Shigeura, Keita Inoue, Noriyuki Aoi, Harunosuke Kato, Satoshi Nishimura, Ichiro Manabe, Koichi Gonda, Kotaro Yoshimura

Spatiotemporal Recapitulation of Central Nervous System Development by Murine Embryonic Stem Cell-Derived Neural Stem/Progenitor Cells
Yohei Okada, Arifumi Matsumoto, Takuya Shimazaki, Ryosuke Enoki, Amane Koizumi, Seiji Ishii, Yasuto Itoyama, Gen Sobue, Hideyuki Okano

Enrichment of Putative Pancreatic Progenitor Cells from Mice by Sorting for Prominin1 (CD133) and Platelet-Derived Growth Factor Receptor β
Yuichi Hori, Miki Fukumoto, Yoshikazu Kuroda

CD105-Positive Cells in Pulmonary Arterial Blood of Adult Human Lung Cancer Patients Include Mesenchymal Progenitors
Haruki Chiba, Genicihro Ishii, Ta-Kashi Ito, Kazuhiro Aoyagi, Hiroki Sasaki, Kanji Nagai, Atsushi Ochiai

Mood Stabilizing Drugs Expand the Neural Stem Cell Pool in the Adult Brain Through Activation of Notch Signaling
Mikito Higashi, Noriko Maruta, Alan Bernstein, Kazuhiro Ikenaka, Seiji Hitoshi

A Novel Isolation Technique of Progenitor Cells in Human Corneal Epithelium Using Non-Tissue Culture Dishes
Seiichi Yokoo, Satoru Yamagami, Takashi Shimada, Tomohiko Usui, Taka-aki Sato, Shiro Amano, Makoto Araie, Junji Hamuro

Spherically Symmetric Mesenchymal Stromal Cell Bodies Inherent with Endogenous Extracellular Matrices for Cellular Cardiomyoplasty
Chung-Chi Wang, Chun-Hung Chen, Shiaw-Min Hwang, Wei-Wen Lin, Chih-Hao Huang, Wen-Yu Lee, Yen Chang, Hsing-Wen Sung

Brief Report - Human Embryonic Stem Cell-Derived Mesenchymal Progenitors Possess Strong Immunosuppressive Effects Toward Natural Killer Cells as Well as T Lymphocytesty
B. Linju Yen, Chan Jung Chang, Ko-Jiunn Liu, Yao Chang Chen, Hsin-I Hu, Chi-Huey Bai, Men-Luh Yen